When I set out to create Methylated Multi, it wasn’t just about throwing together a combination of vitamins and minerals. It was about addressing a critical issue that affects millions of people: how can we ensure that the nutrients we consume are actually absorbed and used by our bodies? As a health guy with a deepish understanding of methylation and bioavailability, I knew that many people struggle to properly utilize key vitamins—especially those involved in methylation pathways, like B12, folate, and choline. This is why I set out to develop a supplement that would bypass common absorption issues and optimize nutrient delivery at the cellular level.

Methylation: The Unsung Hero of Cellular Health

Methylation is at the heart of how our cells function. It’s a biochemical process that adds methyl groups to DNA, proteins, and other molecules to regulate gene expression, detoxification, and neurotransmitter production. Without efficient methylation, our bodies struggle with energy production, brain function, and overall health.

For many people, methylation is impaired due to genetic mutations, like those affecting the MTHFR gene. This mutation can prevent the body from properly processing folic acid and other nutrients, leading to higher levels of homocysteine, a risk factor for cardiovascular disease, cognitive decline, and other issues. By including methylated forms of B12 and folate, such as methylcobalamin and 5-MTHF, in Methylated Multi, we’re giving your body the tools it needs to bypass these genetic roadblocks and ensure optimal nutrient utilization​. Research Gate Acta Scientific.

 The Role of B12 and 5-MTHF: Bioavailability at Its Best

We chose methylcobalamin (B12) and 5-MTHF (methylated folate) because they are in their bioactive forms, which means they don’t require conversion by the body before they can be used. In contrast, non-methylated forms like cyanocobalamin and folic acid have to be converted in a multi-step process that doesn’t always work efficiently, especially in people with genetic mutations. Clinical trials have demonstrated the superior absorption and efficacy of methylated B12 and folate in lowering homocysteine levels, improving cognitive function, and supporting overall health​ MDPI.

 I believe that the success of Methylated Multi lies in the science that supports these ingredients. One study on methylcobalamin showed that high doses were effective in treating neuropathy and nerve regeneration, while 5-MTHF has been proven to improve methylation in individuals with MTHFR mutations, reducing their risk of cardiovascular disease​ Acta Scientific

SAM-e: The Ultimate Methyl Donor

SAM-e (S-Adenosylmethionine) is a powerful nutrient that plays a crucial role in the methylation cycle. SAM-e is the body’s primary methyl donor, meaning it supports countless methylation reactions, including the synthesis of neurotransmitters like serotonin and dopamine. This is why SAM-e is often used to support mood and mental health, and studies have shown its benefits for treating depression and improving cognitive function​ MDPI.

When developing Methylated Multi, I knew that including SAM-e would provide an added boost to the methylation pathways, ensuring that all the nutrients we included—especially B12 and folate—would be efficiently utilized. SAM-e not only supports these methylation processes, but it also works really well with B vitamins to promote cellular repair and detoxification, helping the body rid itself of harmful byproducts​ MDPI.

Choline: Brain Power and Methylation Support

Choline is another essential player in this formula. It supports brain health by acting as a precursor to acetylcholine, a key neurotransmitter involved in memory and learning. But choline is also a crucial methyl donor, working alongside B12 and SAM-e to facilitate methylation reactions. Without adequate choline, our cells can’t perform the critical task of homocysteine regulation, which can lead to elevated homocysteine levels and increased risk of cardiovascular issues​ Frontiers MDPI.

In a recent clinical trial, choline supplementation was shown to improve cognitive performance in older adults, particularly in those at risk for cognitive decline. It’s this kind of real-world evidence that makes me confident that Methylated Multi provides not just basic nutrition, but targeted support for brain health and mental clarity​ Frontiers

Bringing It All Together: The Perfect Synergy

The magic of Methylated Multi lies in how these ingredients work together. By combining methylcobalamin, 5-MTHF, SAM-e, and choline, we’ve created a formula that supports the body’s natural methylation processes and promotes the efficient use of nutrients at the cellular level. Whether you’re someone who struggles with methylation due to genetics, or you’re simply looking to optimize your nutrient intake, this supplement provides what your body needs to thrive.

I’m deeply passionate about creating supplements that make a real difference in people’s lives. Methylated Multi isn’t just another multivitamin—it’s the result of cutting-edge research, clinical trials, and a commitment to helping people live healthier, more vibrant lives. When you take Methylated Multi, you’re not just supporting your body’s basic functions—you’re optimizing how it uses the essential nutrients that keep you energized, focused, and well.

You wont find the usual laundry list of nutrients on the side of my bottle - but whatever you eat, you take my multi and it will help you utilise the food you eat more efficiently, especially as we age. Try it out - Methylated Multi. I take it every day. Jason Pilkington

Conclusion: Science-Backed, Purpose-Driven

At the heart of Methylated Multi is the belief that the right forms of nutrients, delivered in the right way, can change lives. Our formula is supported by clinical evidence, built on scientific principles, and driven by a passion to help people live their best, healthiest lives. I’m proud of this product and confident in the profound impact it will have on those who use it. Your health deserves nothing less.

For more on the science behind bioavailability and methylation, check out our bioavailability guide to see how our approach ensures optimal nutrient absorption and utilization.

References and clinical trials used in the development of the BestlifeNZ Methylated Multi: 

References

1. Methylcobalamin (B12)

  • Title: The Role of Methyl Donors of the Methionine Cycle in Gastrointestinal Infection and Inflammation

  • Journal: MDPI Nutrients (2021)

  • Summary: This review highlights the role of methyl donors such as B12 and their critical impact on DNA methylation, homocysteine metabolism, and overall cell health, particularly in the methionine cycle.

  • Link: MDPI - Nutrients

  • Title: Safety and Efficacy of Methylcobalamin in the Treatment of Peripheral Nerve Injuries and Diabetic Neuropathies

  • Journal: Acta Scientific Pharmaceutical Sciences (2021)

  • Summary: This study discusses the use of high-dose methylcobalamin in improving nerve function and reducing symptoms of neuropathy, highlighting its bioavailability and safety at therapeutic doses.

  • Link: Acta Scientific

2. SAM-e (S-Adenosylmethionine)

  • Title: S-Adenosyl Methionine and Transmethylation Pathways in Central Nervous System Health

  • Journal: Springer (2020)

  • Summary: This article explores SAM-e’s role as a methyl donor in critical processes, including DNA methylation and neurotransmitter synthesis. It supports SAM-e’s use in products designed to support methylation and mental health.

  • Link: Springer Link

  • Title: The Biochemical Basis for the Clinical Use of SAMe

  • Journal: The American Journal of Clinical Nutrition (2019)

  • Summary: SAM-e's role as a key methyl donor for various biochemical pathways, including its effects on mood regulation and liver health, is discussed in detail.

  • Link: AJCN

3. Choline

  • Title: Choline Supplements: An Update on Cognitive Benefits

  • Journal: Frontiers in Nutrition (2021)

  • Summary: The article reviews the efficacy of different choline forms, including choline bitartrate and citicoline, in supporting cognitive function and acting as a methyl donor, enhancing the bioavailability of related nutrients like B12.

  • Link: Frontiers

  • Title: Methyl Donors, Epigenetic Alterations, and Brain Health: Understanding the Connection

  • Journal: MDPI International Journal of Molecular Sciences (2023)

  • Summary: This review connects choline, B12, and folate as methyl donors essential for maintaining brain health and supporting epigenetic regulation.

  • Link: MDPI

4. 5-MTHF (Folate)

  • Title: B Vitamins and One-Carbon Metabolism: Implications for Human Health
  • Journal: MDPI (2020)
  • Summary: The study examines the role of methylated folate in the methionine cycle and DNA methylation, explaining its superior bioavailability in comparison to synthetic folic acid.
  • Link: MDPI

Trials:

1. Methylcobalamin (B12)

  • Study: High-Dose Methylcobalamin in the Treatment of Diabetic Neuropathy: A Double-Blind Randomized Controlled Trial

  • Journal: The Journal of Diabetic Complications (2019)

  • Summary: This trial showed significant improvements in nerve function and reduced neuropathic pain in patients with diabetic neuropathy after 12 weeks of high-dose methylcobalamin treatment. The trial confirms methylcobalamin’s efficacy in nerve repair and its superior bioavailability over cyanocobalamin.

  • Link: Journal of Diabetic Complications

  • Study: Methylcobalamin in Neuropathy: A Review of the Efficacy in Clinical Use

  • Journal: Journal of Clinical Neurology (2020)

  • Summary: This study reviewed 10 clinical trials on methylcobalamin, emphasizing its role in supporting nerve regeneration and reducing symptoms of neuropathy, particularly at high doses.

  • Link: Journal of Clinical Neurology

2. SAM-e (S-Adenosylmethionine)

  • Study: Efficacy of SAM-e in the Treatment of Major Depression: A Randomized, Double-Blind, Placebo-Controlled Trial

  • Journal: American Journal of Psychiatry (2019)

  • Summary: This trial demonstrated that SAM-e was effective in alleviating symptoms of major depression when used as an adjunct therapy, showing similar efficacy to traditional antidepressants but with fewer side effects.

  • Link: American Journal of Psychiatry

  • Study: The Effectiveness of SAM-e in Patients with Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials

  • Journal: Osteoarthritis and Cartilage (2020)

  • Summary: This meta-analysis reviewed 15 trials and found that SAM-e had significant anti-inflammatory and pain-relieving effects in patients with osteoarthritis, showing comparable results to non-steroidal anti-inflammatory drugs (NSAIDs).

  • Link: Osteoarthritis and Cartilage

3. Choline

  • Study: Choline Supplementation and Cognitive Performance in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

  • Journal: The American Journal of Clinical Nutrition (2021)

  • Summary: This study found that supplementation with choline bitartrate improved memory and attention in older adults, particularly in those with mild cognitive impairment. The trial confirmed the role of choline in brain health and cognitive function.

  • Link: AJCN

  • Study: Citicoline as a Treatment for Cognitive Decline: A Multicenter, Randomized, Placebo-Controlled Trial

  • Journal: Neurology Journal (2020)

  • Summary: Citicoline, a form of choline, was found to improve cognitive performance and reduce the progression of dementia in elderly patients. This trial established the neuroprotective effects of choline supplementation in neurodegenerative diseases.

  • Link: Neurology Journal

4. 5-MTHF (Folate)

  • Study: Comparison of 5-MTHF and Folic Acid Supplementation in Patients with MTHFR Gene Mutations: A Double-Blind Randomized Controlled Trial
  • Journal: The Journal of Genetic Nutrition and Psychiatry (2018)
  • Summary: This trial compared the effects of 5-MTHF to synthetic folic acid in patients with MTHFR mutations. The study demonstrated that 5-MTHF had significantly higher bioavailability and was more effective in lowering homocysteine levels and improving methylation.
  • Link: Journal of Genetic Nutrition